Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the TollLike Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells

Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the Toll-Like Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells

Inflammation is a biological response to the immune system to defend the body of negative stimulation. However, the excessive inflammatory response can damage host tissues and pose serious threats. Exopolysaccharide (EPS), one of the postbiotics, is secreted with respect to lactic acid bacteria. Although many studies have described the beneficial effects of EPS, such as its anti-inflammatory and antioxidant effects, its underlying mechanisms have remained poorly understood. Thus, we have identified that the EPS obtained from Lactobacillus Plantarum L-14 were homogeneous polysaccharide composed mainly of glucose. To examine these anti-inflammatory effects, an inflammatory response has been induced by the administration of lipopolysaccharide (LPS) with pretreated Mouse 264.7 mouse and EPS macrophage cells.

The anti-inflammatory effects of EPAs have been identified by analyzing changes in inflammatory markers at the molecular level. We demonstrate here that the preflammatory mediators of the EPS have removed EPS, such as cyclooxygenase-2, interleukin-6, the tumor-α-α and interleukin-1β factor and decreased the expression of An inducible nitric oxide synthase known to cause an oxidative constraint. It has also been confirmed that the EPA had anti-inflammatory effects by blocking the LPS interaction with a toll (TLR4) receptor (TLR4), as demonstrated using TAK-242 TLR4 inhibitor. In addition, we found that the EPS itself could delete the expression of TLR4. Therefore, our data suggest that EPAs can be a potential target for the development of natural drug derivative drugs to treat inflammatory diseases related to TLR4.

The preconditioning of mycophenolate Mofofetil protects the liver from the mouse against the ischemia / lesion of the ePaction in the wild type and <em> toll </ em> – <em> like </ em> <em> receiver </ em> <em> 4 </ em> knockout and mouse

Context: Mycophenolate Mofetil (MMF), Immunosuppressive drug, exerts anti-inflammatory effects on the organs during an injury to ischemia / reperfusion (I / R). However, the exact function of MMF in a hepatic injury I / R remains largely unknown. The purpose of this study was to explore the role and the potential mechanism of MMF protection in Hepatic Injuries I / R.

Methods: Male Wild Type (WT) and TLR4 Knockout (KO) The mice were injected intraperitoneally with MMF or normal saline. The animals suffered 90 minutes of partial hepatic ischemia, followed by 1, 6 or 24 hours of reperfusion. Hepatic Histology, serum amiotransferase, inflammatory cytokines, apoptosis of hepatocytes and hepatocyte autophagia were examined to evaluate liver injuries.

Results: The treatment with MMF has decreased considerably of a hepatic injury I / R, as indicated by a reduction in serum aminotransferase levels, suzuki scores and the general degree of necrosis. MMF processing has significantly inhibited TLR4 activation. The MMF administration has also significantly inhibited the activation of the NF-KB channel and the expression of pro-inflammatory cytokines. In the mice TLR4 KO, MMF has always exerted protection against hepatic injuries I / R. The MMF treatment has inhibited the apoptosis of the hepatocyte, as indicated by the reduced tunnel coloring and reduces the accumulation of clevered caspase. 3. In addition, MMF can induce autophagy and increase the self-phage flow before and after hepatic reperfusion by increasing the expression of LC3-II, P62 and Beclin-1. The induction of autophagy by MMF treatment can be linked to TLR4 activation.

Conclusions: Our results indicate that MMF processing improves hepatic injury I / A. The action mechanism probably involves MMF’s ability to reduce apoptosis and inflammatory response while inducing autophagy.

Exopolysaccharide Isolated from <i>Lactobacillus plantarum</i> L-1<em>4</em> Has Anti-Inflammatory Effects via the <em>Toll</em>-<em>Like</em> <em>Receptor</em> <em>4</em> Pathway in LPS-Induced RAW 26<em>4</em>.7 Cells
Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the TollLike Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells

 

Statins inhibit <em> toll </ em> – <em> like </ em> <em> </ em> <em> 4 </ em> medicated growth of adenocarcinoma cells of human esophagus

Background: Oesophageal adenocarcinoma (EAC) is a deadly malignancy with a bad prognosis. Pharmacological inhibitors of inflammation, such as statins, have been demonstrated to reduce the risk of development and progression of esophagus cancer, but the mechanism of this protection is not clear. The objective of this study was to elucidate the effect of statins on the toll receptor of the mediation proliferation of the human face and to identify the mechanism responsible for these observed effects.

Methods: Human EAC cells (OE33 and FLO1) have been treated with simvastatin or atorvastatin to increase doses and periods of time. The expression of the till type 4 (TLR4) has been evaluated. The cells were pretreated with the statin followed by lipopolysaccharide (LPS). Cell proliferation and the expression of signaling proteins have been evaluated. FLO1 cells were injected into the naked mouse side. The mice received intraperitoneal injections of the simvastatin, atorvastatin or the control solution and the volume of the tumor was measured.
Results: OE33 and FLO1 cells have demonstrated reduced expression of TLR4 after treatment with simvastatin or atorvastatin for 8 h (p <0.05). The increased proliferation of the LPS, while pretreatment with the statin abolished this response (p <0.05). Statins decreased the expression and activation of LPS-induced signaling proteins, including MyD88, Traf6, AKT and NF-κB (p <0.05). Mice receiving statin daily injections have demonstrated smaller tumors than control mice (p <0.001 to day 33).

Conclusions: The treatment of EAC cells with simvastatin or atorvastatin decreases the mediation proliferation of the TLR4 and the growth of the Vivo tumor. The decrease in the expression of TLR4 and a subsequent reduction of the dependent signaling of MyD88 could be a mechanism by which statins act to reduce tumor growth rates.

Rat Monoclonal anti-mouse IL-9 Receptor

mAP-0115 100ug
EUR 250

IL-9 Receptor Mouse mAb

E2222369 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

IL-9 Receptor Rabbit pAb

E2163037 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-IL-6 receptor (Tocilizumab), Human IgG1 Antibody

A1447-200 each
EUR 933.6

Anti-Human IL-17 receptor Antibody

101-M484 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Anti-Human IL-21 receptor Antibody

101-M505 100 µg
EUR 399
Description: IL-21 R, also called NILR (novel interleukin receptor) is a type I cytokine receptor with four conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta and IL-9 R alpha. Mouse and human IL-21 R share 62% amino acid identity. IL-21 R is expressed on lymphoid tissues, peripheral B cells, and cell lines of T, B and natural killer cell lineage. IL-21 mediated signaling requires the common gamma chain in addition to IL-21 R.

Anti-Human IL-17B receptor Antibody

101-M486 100 µg
EUR 399
Description: IL-17B receptor (IL-17B R), also known as IL-17Rh1, IL-17ER and EVI27, is a 502 amino acid (aa) type I membrane protein with a 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. By alternative splicing, a secreted variant of IL-17B R has also been identified.

Interleukin-1 Receptor 9 (IL-1R9) Antibody

20-abx216200
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

anti-CD25 IL-2 receptor

511-A-01mg 0,1 mg
EUR 321
Description: anti-CD25 IL-2 receptor expressed on activated T and B cells

anti-CD25 IL-2 receptor

511-A-1000ug 1000 ug
EUR 1539
Description: anti-CD25 IL-2 receptor expressed on activated T and B cells

Anti-IL-23 Receptor Antibody

A00607 200ug
EUR 476.4
Description: Goat Polyclonal IL-23 Receptor Antibody. Validated in IF, IHC and tested in Human, Mouse.

pAb rabbit anti-human IL-4 receptor

CT248 0.5 mg
EUR 220.8

Anti-Human IL-2 receptor beta Antibody

101-M711 100 µg
EUR 399
Description: IL-2 Receptor beta in frozen human lymph node. View IL-2 R beta IHC images. IL-2 R beta is a 551 amino acid (aa) precursor type I membrane protein with a 26 aa signal peptide, a 214 aa extracellular region, a 25 aa transmembrane region and a 286 aa cytoplasmic domain. IL-2 R beta binds IL-2 as a part of the IL-2 R alpha/IL-2 R beta/common gamma chain complex.

Anti-Human IL-1 Receptor Type I (IL-1RI) Antibody

GWB-51DA56 1 mL Ask for price

Anti-Human IL-2 receptor alpha Antibody

102-P47 100 µg
EUR 245.7
Description: The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R alpha, IL-2R beta, and IL-2R gamma. The IL-2R alpha is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R alpha releases the entire extracellular domain of IL-2R alpha thereby generating a 219 amino acid soluble protein called soluble IL-2R alpha (sIL-2R alpha). The homodimeric form binds IL-2 (KD=10mM) and facilitates IL-2 signaling. The secreted sIL-2R alpha is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R alpha is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R alpha. Due to glycosylation, IL-2R alpha has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.

Anti-Human IL-10 receptor beta Antibody

101-M473 100 µg
EUR 399
Description: IL-10 mediates its biological activities via binding to a heteromeric complex of two distinct type II cytokine receptor subunits, the ligand binding subunit IL-10 R alpha (IL-10 R1) and the signal-transducing accessory subunit IL-10 R beta (IL-10 R2). IL-10 R alpha is specific for IL-10 and expressed by most hemopoietic cells. IL-10 R beta is a widely expressed shared subunit for IL-10, IL-22, IL-26 and the IFNl proteins IL-28A, IL-28B and IL-29.

Anti-Human IL-18 receptor beta Antibody

101-M494 100 µg
EUR 399
Description: The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor family. Although IL-18 R alpha by itself binds IL-18 with low-affinity and IL-18 R beta does not bind IL-18 in vitro, co-expression of IL-18 R alpha and IL-18 R beta is required for high-affinity binding and IL-18 responsiveness. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. It is not expressed in brain, skeletal muscle, kidney and pancreas.

Anti-Human IL-7 receptor alpha Antibody

101-M509 100 µg
EUR 399
Description: The biological effects of IL-7 are mediated by the binding of IL-7 to the specific cell surface receptor complex. The functional high-affinity IL-7 receptor (IL-7 R) comprises the IL-7 R alpha chain in association with the common gamma chain (gamma c). Both IL-7 R alpha and gamma c are members of the hematopoietin receptor superfamily. Human and mouse IL-7 R alpha show 64% amino acid sequence identity. IL-7 R alpha transcripts were observed in murine spleen, thymus, fetal liver, developing T cells, B cells, mature T cells and bone marrow-derived macrophages.

Anti-Human IL-2 receptor alpha Antibody

101-M710 100 µg
EUR 399
Description: IL2-Ra is one of the three constituent subunits of the IL2 receptor. IL-2Ra is released into the serum after increased cellular expression such as increased activation of B and T cells. Clinical manifestations of IL2-Ra elevation include autoimmune conditions and some leukemias and lymphomas. Interleukin-2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (22-213) corresponding to the mature IL2-R protein with an amino terminal hexahistidine tag. The IL-2R is purified by proprietary chromatographic techniques.

Anti-Human IL-3 receptor alpha Antibody

101-M719 100 µg
EUR 399
Description: Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.

Anti-Human IL-1 Receptor Type II (IL-1RII) Antibody

GWB-5CE391 1 mL Ask for price

Anti-Human IL-1 Receptor Type II (IL-1RII) Antibody

GWB-AD8053 1 mg Ask for price

Anti-Human IL-10 receptor alpha Antibody

101-M472 100 µg
EUR 399
Description: Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.

Anti-Human IL-12 receptor beta1 Antibody

101-M476 100 µg
EUR 399
Description: The biological activities of IL-12 are mediated through a receptor complex composed of two class I cytokine receptor subunits designated IL-12 R beta 1 and IL-12 R beta 2. Both subunits are required for high-affinity binding and activity of IL-12. IL-12 R beta 1 binds specifically to IL-12 p40, a subunit of the heterodimeric IL-12, and is also a subunit of the IL-23 receptor complex, while IL-12 R beta 2 binds IL-12 p35. IL-12 Rs are predominantly expressed on NK cells and activated T (Th1) cells with some expression also on dendritic cells. Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain.

Anti-Human IL-13 receptor alpha Antibody

101-M478 100 µg
EUR 399
Description: Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Anti-Human IL-15 receptor alpha Antibody

101-M481 100 µg
EUR 399
Description: Interleukin 15 receptor alpha (IL-15 R alpha) is a high affinity receptor that specifically binds IL-15 and associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of Tand B cells as well as non-lymphoid cells. Human IL-15 R alpha shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

Anti-Human IL-18 receptor alpha Antibody

101-M493 100 µg
EUR 399
Description: Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta

Anti-Human IL-20 receptor alpha Antibody

101-M504 100 µg
EUR 399
Description: IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

Anti-Human IL-2 receptor, soluble Antibody

101-M165 500 µg
EUR 246.75
Description: Human IL-2 exerts its biological effects via signaling through its receptor system, IL-2R. IL-2 and its receptor (IL-2R) are required for T-cell proliferation and other fundamental functions which are crucial of the immune response. IL-2R consists of 3 noncovalently linked type I transmembrane proteins which are the alpha (p55), beta (p75), and gamma (p65) chains. The IL-2R alpha chain contains an extracellular domain of 219 amino acids, a transmembrane domain of 19 amino acids, and an intracellular domain of 13 amino acids. The secreted extracellular domain of IL-2R alpha (s-IL-2R-a), also called TAC-antigen, is expressed on leukemia cells, lymphoma cells, approximately 10% NK cells, as well as recently activated T and B cells. Recombinant human s-IL-2R-a is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R alpha. Due to glycosylation, IL-2R alpha has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.

IL-2 Receptor ?, Human Recombinant

7100-10 each
EUR 235.2

IL-2 Receptor ?, Human Recombinant

7100-50 each
EUR 764.4

IL-1 Receptor Peptide (human)

5-01372 4 x 5mg Ask for price

IL-1 Receptor Peptide (human)

H-1386.0001 1.0mg
EUR 691.2
Description: Sum Formula: C47H88N14O12S; CAS# [141801-03-8] net

IL-1 Receptor Peptide (human)

H-1386.0005 5.0mg
EUR 2648.4
Description: Sum Formula: C47H88N14O12S; CAS# [141801-03-8] net

Anti-Human IL-1 receptor antagonist Antibody

101-M501 100 µg
EUR 399
Description: IL-1 receptor antagonist (IL-1ra) was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1RII does not bind IL-1ra.

Anti-Human IL-1 Receptor Antagonist Antibody

GWB-268D1A 1 mg Ask for price

Anti-Mouse IL-6 receptor Antibody

103-M255 100 µg
EUR 399
Description: The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R) and a signal-transducing component of 130 kDa (gp 130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human and murine IL-6 R alphas have been constructed, however, by insertion of termination codons into the regions of the IL-6 R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6 R alpha complex to membrane-bound gp130.

Anti-IL-2 receptor alpha Antibody

HA500076 100ul
EUR 189
Description: Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.

Anti-Mouse IL-17 receptor Antibody

103-M245 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Anti-Mouse IL-18 receptor Antibody

103-M247 100 µg
EUR 399
Description: Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa residues. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.

Anti-Mouse IL-21 receptor Antibody

103-M250 100 µg
EUR 399
Description: IL-21 R, also called NILR (novel interleukin receptor) is a type I cytokine receptor with four conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta and IL-9 R alpha. Mouse and human IL-21 R share 62% amino acid identity. IL-21 R is expressed on lymphoid tissues, peripheral B cells, and cell lines of T, B and natural killer cell lineage. IL-21 mediated signaling requires the common gamma chain in addition to IL-21 R.

Anti-Mouse IL-23 receptor Antibody

103-M251 100 µg
EUR 399
Description: The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2.

Anti-Mouse IL-17B receptor Antibody

103-M246 100 µg
EUR 399
Description: IL-17B receptor (IL-17B R), also known as IL-17Rh1, IL-17ER and EVI27, is a 502 amino acid (aa) type I membrane protein with a 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail. By alternative splicing, a secreted variant of IL-17B R has also been identified.

Anti-Human IL-13 receptor alpha 2 Antibody

101-M479 100 µg
EUR 399
Description: Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Human Interleukin 33 receptor (IL-33 receptor)ELISA Kit

SL3314Hu 96 Tests
EUR 468

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

AP74791 1mg
EUR 1369

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-10ug 10ug
EUR 108
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-1mg 1mg
EUR 1131.6
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-500ug 500ug
EUR 808.8
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Recombinant Human IL-1 Receptor Antagonist Protein/IL-1RA/IL-1F3

C033-50ug 50ug
EUR 181.2
Description: Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.

Anti-Human IL-4 receptor alpha, soluble Antibody

102-P106 100 µg
EUR 245.7
Description: IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc).  The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα.  The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity.  It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. 

Rabbit Anti Human Il-27 Receptor Alpha (C-Terminal) Polyclonal Antibody

CPBT-65700RH 0.1 mg
EUR 795.6

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

AP74818 1mg
EUR 3209

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

C071-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

PKSH033872-10ug 10ug
EUR 206
Description: Human

Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5

PKSH033872-50ug 50ug
EUR 619
Description: Human

Recombinant Human IL-21 Receptor/IL-21R (C-6His)

CC81-10ug 10ug
EUR 114
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.

Recombinant Human IL-21 Receptor/IL-21R (C-6His)

CC81-1mg 1mg
EUR 1094.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.

Recombinant Human IL-21 Receptor/IL-21R (C-6His)

CC81-500ug 500ug
EUR 850.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.

Recombinant Human IL-21 Receptor/IL-21R (C-6His)

CC81-50ug 50ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.

Recombinant Human IL-21 Receptor/IL-21R (C-6His)

AP75578 1mg
EUR 1319

Human Toll Like Receptor 9 (TLR-9) ELISA Kit

NSL1604Hu 96 wells
EUR 468

anti-IL-13 receptor α 2 (2E10)

LF-MA10146 100 ug
EUR 435.6
Description: Mouse monoclonal to IL-13 receptor α 2

Human Anti-IgE Receptor Antibody (Anti-IgE Receptor) ELISA Kit

abx053524-96tests 96 tests
EUR 801.6

Anti-Olfactory receptor O13C2/9 antibody

STJ94824 200 µl
EUR 236.4
Description: Rabbit polyclonal to Olfactory receptor O13C2/9.

Human Toll Like Receptor 9 ELISA

E01A8157 96T
EUR 700
Description: ELISA

Human Toll-like receptor 9,TLR-9 ELISA kit

201-12-0357 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Toll-like receptor 9(TLR-9) Elisa Kit

EK711478 96 Wells
EUR 0.18

Human Toll-like receptor 9,TLR-9 ELISA kit

EKC40697-48T 48T
EUR 474.04

Human Toll-like receptor 9,TLR-9 ELISA kit

EKC40697-5x96T 5x96T
EUR 3216.7

Human Toll-like receptor 9,TLR-9 ELISA kit

EKC40697-96T 96T
EUR 677.2

Human Toll-like receptor 9, TLR-9 ELISA kit

CSB-E09821h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Toll-like receptor 9, TLR-9 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Toll-like receptor 9, TLR-9 ELISA kit

1-CSB-E09821h
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Toll-like receptor 9, TLR-9 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Toll-like receptor 9,TLR-9 ELISA kit

CN-04125H1 96T
EUR 577.2

Human Toll-like receptor 9,TLR-9 ELISA kit

CN-04125H2 48T
EUR 398.4

Human Toll-like receptor 9 (TLR-9) ELISA Kit

RK12260 96T
EUR 280

Human Toll-like receptor 9,TLR-9 ELISA Kit

SL1723Hu 96 Tests
EUR 468

Human Toll-like receptor 9,TLR-9 ELISA kit

YLA0453HU-48T 48T Ask for price

Human Toll-like receptor 9,TLR-9 ELISA kit

YLA0453HU-96T 96T Ask for price

Rabbit Anti-Human Interleukin 6 receptor (IL-6RCD126, gp80/IL-6RA)

AB-22124 50 ul
EUR 562.8

Anti-Mouse IL-2 receptor beta Antibody

103-M248 100 µg
EUR 399
Description: IL-2 R beta is a 551 amino acid (aa) precursor type I membrane protein with a 26 aa signal peptide, a 214 aa extracellular region, a 25 aa transmembrane region and a 286 aa cytoplasmic domain. IL-2 R beta binds IL-2 as a part of the IL-2 R alpha/IL-2 R beta/common gamma chain complex.

Anti-Mouse IL-3 receptor beta Antibody

103-M253 100 µg
EUR 399
Description: The high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.

Anti-Mouse IL-3 receptor alpha Antibody

103-M252 100 µg
EUR 399
Description: Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.

Anti-Mouse IL-4 receptor alpha Antibody

103-M254 100 µg
EUR 399
Description: Two types of IL-4 receptor complexes have been described. The typeI IL-4 receptor complex is composed of a high-affinity IL-4-binding subunit (referred to as IL-4 R or IL-4 R alpha) and the common gamma chain that does not bind IL-4 by itself. The type II IL-4 receptor complex is composed of IL-4 R and IL-13 R alpha 1. Besides IL-4 signals, the type II IL-4 receptor complex can also transduce IL-13 signals. In the type II complex, IL-4 R subunit binds only IL-4 and not IL-13. Similarly, the IL-13 R alpha 1 subunit binds only IL-13 and not IL-4.

Anti-Mouse IL-7 Receptor alpha Antibody

103-M426 100 µg
EUR 399
Description: The biological effects of IL-7 are mediated by the binding of IL-7 to the specific cell surface receptor complex. The functional high-affinity IL-7 receptor (IL-7 R) comprises the IL-7 R alpha chain in association with the common gamma chain (gamma c). Both IL-7 R alpha and gamma c are members of the hematopoietin receptor superfamily. Human and mouse IL-7 R alpha show 64% amino acid sequence identity. IL-7 R alpha transcripts were observed in murine spleen, thymus, fetal liver, developing T cells, B cells, mature T cells and bone marrow-derived macrophages.

Human Toll-Like Receptor 9, TLR-9 GENLISA ELISA

KBH0356 1 x 96 wells
EUR 286

Anti-Mouse IL-10 receptor alpha Antibody

103-M242 100 µg
EUR 399
Description: Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.

Anti-Mouse IL-15 receptor alpha Antibody

103-M244 100 µg
EUR 399
Description: Interleukin 15 receptor alpha (IL-15 R alpha) is a high affinity receptor that specifically binds IL-15 and associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of Tand B cells as well as non-lymphoid cells. Human IL-15 R alpha shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

Anti-Mouse IL-20 receptor alpha Antibody

103-M249 100 µg
EUR 399
Description: IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.

Anti-Mouse IL-15 receptor alpha Antibody

103-M25 100 µg
EUR 399
Description: Interleukin 15 receptor alpha (IL-15 R alpha) is a high affinity receptor that specifically binds IL-15 and associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of Tand B cells as well as non-lymphoid cells. Human IL-15 R alpha shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.

Mouse Anti-Human IL-15 Receptor Purified (100 ug)

TA320359 100 µg Ask for price

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-48T 48T Ask for price

Human anti-IgE receptor antibody(anti-IgE receptor antibody)ELISA Kit

YLA0043HU-96T 96T Ask for price

Rat Monoclonal anti-mouse IL-4 Receptor

mAP-0113 100ug
EUR 250

Rat Monoclonal anti-mouse IL-6 Receptor

mAP-0114 100ug
EUR 250

Anti-Mouse IL-1 receptor antagonist Antibody

103-M413 100 µg
EUR 399
Description: IL-1 receptor antagonist (IL-1ra) was originally isolated from the urine of patients with monocytic leukemia and has also been purified from adherent monocytes. The protein shows 26% amino acid homology to IL-1 beta and 19% homology to IL-1 alpha. It will compete with either factor for receptor binding, but does not interact with either one. Human IL-1ra will bind to both types of IL-1 receptor (I and II) on human cells. In mouse, IL-1RII does not bind IL-1ra.

Anti-Interleukin-1 Receptor (IL-1R) Antibody

40101 200ug
EUR 391

Anti-Interleukin-1 Receptor (IL-1R) Antibody

40102 200ug
EUR 391

Anti-Interleukin-1 Receptor (IL-1R) Antibody

40103 200ug
EUR 391

Rat Monoclonal anti-mouse IL-17 Receptor

mAP-0104 100ug
EUR 250

Rat Monoclonal anti-mouse IL-18 Receptor

mAP-0106 100ug
EUR 250

Rat Monoclonal anti-mouse IL-21 Receptor

mAP-0109 100ug
EUR 250

Rat Monoclonal anti-mouse IL-23 Receptor

mAP-0110 100ug
EUR 250

Rat Monoclonal anti-mouse IL-17B Receptor

mAP-0105 100ug
EUR 250

IL-1RA, Interleukin-1 receptor antagonist, human

RC212-12C 20ug
EUR 125.26

Anti-Olfactory receptor 8U1/8/9 antibody

STJ94818 200 µl
EUR 236.4
Description: Rabbit polyclonal to Olfactory receptor 8U1/8/9.

Anti-Toll-like receptor 9 TLR9 Antibody

A00198-1 0.1mg
EUR 449
Description: Boster Bio Anti-Toll-like receptor 9 TLR9 Antibody (Catalog # A00198-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Anti-Toll-like receptor 9 TLR9 Antibody

A00198-2 0.1mg
EUR 449
Description: Boster Bio Anti-Toll-like receptor 9 TLR9 Antibody (Catalog # A00198-2). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Acute myeloid leukemia (AML) is one of the most serious blood cancers. Many studies have revealed that inflammation plays a vital role in the progression of hematopoietic malignants. Since the path of the till type 4 (TLR4), an important path involved in the induction of inflammation has already been associated with solid tumors, we hypothesized that it would be correlated with the physiopathological characteristics of patients AML and could be considered an anticancer target.

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