Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the TollLike Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the Toll-Like Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the main causes of cancer death around the world. The activation of the differentiation of the 4 / myeloid receiver type main response gene 88 / nuclear factor-κB (TLR4 / MyD88 / NF-κB) contributes to the development and progression of HCC. The ubiquitine-proteasome system regulates the TLR4 expression. However, if the PEPTIDASE 13 (USP13) specific to Ubiquitin (USP13) stabilizes TLR4 and facilitates the progression of HCC remains uncertain.

Here, a quantitative analysis of real-time PCR (QRT-PCR) and immunohistochemistry revealed that the USP13 expression in HCC tissues was greater than that of non-tumor focoise tissues. In addition, the high expression of USP13 was detected in HCC cells (SK-HEP-1, HEPG2, HUH7 and HEP3B) relative to LO2 cells. Interestingly, the positive staining of USP13 was closely correlated at the tumor size ≥ 5 cm and at the stage of the advanced tumor and conferred on a significantly lower survival of patients with SCH. Then, USP13 Hashingdown has significantly reduced proliferation, epithelial-messenchymatory transition (EMT), migration and invasion of HEP3B and HUH7 cells, while USP13 overexpression improved these biological behaviors of HEPG2 and LO2 cells.

The silence of USP13 has significantly limited the growth and pulmonary metastasis of HCC cells in vivo. Mechanically, USP13 depletion significantly marked the TLR4 / MYD88 / NF-κB channel in HCC cells. USP13 interacted with TLR4 and inhibited the degradation of the Ubiquitine-mediated TLR4. Significantly, the TLR4 re-expression remarkably reversed the effects of USP13 isolation on HCC cells. The USP13 expression was clearly regulated in HCC cells under hypoxia conditions. NOTABLY, USP13 BULLDOWN has repressed the activation induced by hypoxia of the TLR4 / MYD88 / NF-κB channel in HCC cells. In conclusion, our study discovered that the USP13 induced by hypoxia facilitated HCC progression through the improvement of TLR4 desubility and the subsequent activation of the TLR4 / MYD88 / NF-KB channel.

 

Preparation of anti-em> toll </ em> – <em> like </ em> <em> </ em> – <em> 4 </ em> nano-antibodies and its effect on the negative sepsy of Gram negative

The essence of sepsis is the excessive immune response caused by infectious factors, resulting in the release of a large number of inflammatory factors and the injury of tissues and organs. Once the reaction is triggered, it will develop according to its own rules and will not depend on infection factors. The occurrence and severity of sepsis depend entirely on the body’s reaction. When pathogens invade the body, they rely on pattern recognition receivers to play a defensive role, TLR4 is the main switch of innate immunity. Current research shows that the LPS can induce the subsequent regulation of TLR4 gene expression in monocytes, neutrophils and other immune cells. The regulated TLR4, as a new receiver, mediate more cell activation and the release of inflammatory mediators.

Under this positive return, the inflammatory response is constantly amplified, which finally leads to the development of sepsis. In this study, the TLR4 extracellular domain antigen was obtained by the expression and purification of proteins, as well as the anti-TLR4 C-terminal and intermediate domain nano-antibody were obtained by the technology for preparing the Anti-phage antibody library. The in vitro and in vivo experiments confirmed that anti-TLR4 antibody can effectively reduce the release of inflammatory factors and improve the survival rate of animals, while the C-terminal and intermediate terminal are closed at the same time, The effect is more obvious. . The clinical treatment of sepsis provides new ideas and strategies.

 Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the <em>Toll</em>-<em>Like</em> <em>Receptor</em> <em>4</em>/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma
Hypoxia-Inducible Ubiquitin Specific Peptidase 13 Contributes to Tumor Growth and Metastasis via Enhancing the TollLike Receptor 4/Myeloid Differentiation Primary Response Gene 88/Nuclear Factor-κB Pathway in Hepatocellular Carcinoma

Activation of <em> toll </ em> <em> as </ em> <em> </ em> <em> 4 </ em> (TLR <em> 4 </ em>) promotes apoptosis cardiomyocyte through Sirt2 dependent p53 deacetylation

Cardiomyocyte inflammation followed by apoptosis and fibrosis is an important mediator for the development and progression of heart failure. Activating the type 4 receptor (TLR4), an important inflammation regulator, causes progression of cardiac hypertrophy and injury. However, the precise mechanism of the adverse cardiac results of the TLR4 is still elusive. This study was designed to find the role of TLR4 in cardiac fibrosis and apoptosis and its molecular mechanism.

The rats were treated with a TLR4 agonist (LPS 12.5 μg / kg / day) by the osmotic pump for 14 days. To simulate the in vitro condition, H9C2 cells were treated with LPS (1 μg / ml). Similarly, H9C2 cells were transfected with the TLR4 and Sirt2 C-DNA clone for overexpression. The oxidative stress of myocardial, inflammation, fibrosis and mitochondrial parameters have been evaluated both in vitro and in vivo. Cardiac inflammation after the treatment of LPS has been confirmed by an increased expression of TNF-α and IL-6 in the rat’s heart. There was a marked increase in oxidative stress as observed by the increase of the Tbars and a decrease in endogenous antioxidants (GSH and Catalase), as well as mitochondrial dysfunction, as measured by a mitochondrial complex activity in the hearts of rats treated by The LPS. Histopathological examination showed the presence of cardiac fibrosis after the treatment of LPS. The expression of proteins of the nuclear P53 and CASPASE-7-7 / CASPASE-9 has been considerably increased in the LP-treated heart.

AVP Receptor V3 Polyclonal Antibody

ABP57860-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AVP Receptor V3 from Human, Mouse, Rat. This AVP Receptor V3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AVP Receptor V3 protein at amino acid sequence of 271-320

AVP Receptor V3 Polyclonal Antibody

ABP57860-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AVP Receptor V3 from Human, Mouse, Rat. This AVP Receptor V3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AVP Receptor V3 protein at amino acid sequence of 271-320

AVP Receptor V3 Polyclonal Antibody

ES1737-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AVP Receptor V3 from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AVP Receptor V3 Polyclonal Antibody

ES1737-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AVP Receptor V3 from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AVP Receptor V3 Polyclonal Antibody

ES8759-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AVP Receptor V3 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

AVP Receptor V3 Polyclonal Antibody

ES8759-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AVP Receptor V3 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Anti-AVP Receptor V3 antibody

STJ91789 200 µl
EUR 236.4
Description: Rabbit polyclonal to AVP Receptor V3.

Anti-AVP Receptor V3 antibody

STJ98822 200 µl
EUR 236.4
Description: Rabbit polyclonal to AVP Receptor V3.

AVP Receptor V3 Polyclonal Conjugated Antibody

C46878 100ul
EUR 476.4

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Ra-48T 48T
EUR 633.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

DLR-AVPR1B-Ra-96T 96T
EUR 828
Description: A sandwich quantitative ELISA assay kit for detection of Rat Arginine Vasopressin Receptor 1B (AVPR1B) in samples from tissue homogenates or other biological fluids.

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Hu-48Tests 48 Tests
EUR 600

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Hu-96Tests 96 Tests
EUR 830.4

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Mu-48Tests 48 Tests
EUR 613.2

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Mu-96Tests 96 Tests
EUR 850.8

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Ra-48Tests 48 Tests
EUR 640.8

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RD-AVPR1B-Ra-96Tests 96 Tests
EUR 890.4

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Hu-48Tests 48 Tests
EUR 626.4

Human Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Hu-96Tests 96 Tests
EUR 868.8

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Mu-48Tests 48 Tests
EUR 640.8

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Mu-96Tests 96 Tests
EUR 890.4

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Ra-48Tests 48 Tests
EUR 669.6

Rat Arginine Vasopressin Receptor 1B (AVPR1B) ELISA Kit

RDR-AVPR1B-Ra-96Tests 96 Tests
EUR 931.2

Vasopressin V3 Receptor Antibody

20-abx121948
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Vasopressin V1b Receptor (AVPR1B) Antibody

20-abx119677
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Vasopressin V1b Receptor (AVPR1B) Antibody

abx027766-400ul 400 ul
EUR 627.6

Vasopressin V1b Receptor (AVPR1B) Antibody

abx027766-80l 80 µl
EUR 343.2

Vasopressin V1b Receptor (AVPR1B) Antibody

abx030536-400ul 400 ul
EUR 627.6

Vasopressin V1b Receptor (AVPR1B) Antibody

abx030536-80l 80 µl
EUR 343.2

Vasopressin V1b Receptor (AVPR1B) Antibody

abx431834-200ul 200 ul
EUR 460.8

Vasopressin V1b Receptor (AVPR1B) Antibody

abx432386-200ul 200 ul
EUR 460.8

Vasopressin V3 Receptor Blocking Peptide

20-abx161788
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

AVP Receptor V2 Polyclonal Antibody

46898-100ul 100ul
EUR 302.4

AVP Receptor V2 Polyclonal Antibody

46898-50ul 50ul
EUR 224.4

AVP Receptor V2 Polyclonal Antibody

ABP55727-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human. This AVP Receptor V2 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AVP Receptor V2 at AA range: 40-120

AVP Receptor V2 Polyclonal Antibody

ABP55727-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human. This AVP Receptor V2 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AVP Receptor V2 at AA range: 40-120

AVP Receptor V2 Polyclonal Antibody

ABP55727-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human. This AVP Receptor V2 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AVP Receptor V2 at AA range: 40-120

AVP Receptor V2 Polyclonal Antibody

ABP57859-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human, Mouse. This AVP Receptor V2 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AVP Receptor V2 protein at amino acid sequence of 1-50

AVP Receptor V2 Polyclonal Antibody

ABP57859-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human, Mouse. This AVP Receptor V2 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AVP Receptor V2 protein at amino acid sequence of 1-50

AVP Receptor V2 Polyclonal Antibody

ABP57859-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AVP Receptor V2 from Human, Mouse. This AVP Receptor V2 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AVP Receptor V2 protein at amino acid sequence of 1-50

AVP Receptor V2 Polyclonal Antibody

ES8846-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AVP Receptor V2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

AVP Receptor V2 Polyclonal Antibody

ES8846-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AVP Receptor V2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

AVP Receptor V2 Polyclonal Antibody

ES6726-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AVP Receptor V2 from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AVP Receptor V2 Polyclonal Antibody

ES6726-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AVP Receptor V2 from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Anti-AVP Receptor V2 antibody

STJ91788 200 µl
EUR 236.4
Description: Rabbit polyclonal to AVP Receptor V2.

Anti-AVP Receptor V2 antibody

STJ99319 200 µl
EUR 236.4
Description: Rabbit polyclonal to AVP Receptor V2.

AVPR1B antibody

70R-34372 100 ug
EUR 392.4
Description: Rabbit polyclonal AVPR1B antibody

AVPR1B Antibody

46325-100ul 100ul
EUR 302.4

AVPR1B Antibody

ABD13023 100 ug
EUR 525.6

AVPR1B Antibody

ABD5170 100 ug
EUR 525.6

AVPR1B Antibody

1-CSB-PA000962
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVPR1B. Recognizes AVPR1B from Human. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

AVPR1B Antibody

1-CSB-PA657802
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVPR1B. Recognizes AVPR1B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC-p:1:50-300, ELISA:1:10000-20000

AVPR1B Antibody

DF5170 200ul
EUR 420

Avpr1b Antibody

1-CSB-PA15639A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Avpr1b. Recognizes Avpr1b from Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

AVPR1B Antibody

R34558-100UG 100 ug
EUR 399

AVPR1B Antibody

R35132-100UG 100 ug
EUR 399

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody

20-abx110673
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody

20-abx324233
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody

20-abx326883
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody

20-abx175466
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody

20-abx175467
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

AVP Antibody

47965-100ul 100ul
EUR 302.4

AVP Antibody

DF14629 100ul
EUR 420

AVP Antibody

1-CSB-PA11069A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVP. Recognizes AVP from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

AVP Receptor V2 Polyclonal Conjugated Antibody

C46898 100ul
EUR 476.4

Rat Vasopressin V1b receptor (Avpr1b)

1-CSB-RP156394r(A4)
  • EUR 606.00
  • EUR 318.00
  • EUR 2192.40
  • EUR 919.20
  • EUR 1461.60
  • EUR 402.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Rat Vasopressin V1b receptor(Avpr1b),partial expressed in E.coli

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody (HRP)

20-abx109236
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody (Biotin)

20-abx106407
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Arginine Vasopressin Receptor 1B (AVPR1B) Antibody (FITC)

20-abx107819
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

AVPR1B Conjugated Antibody

C46325 100ul
EUR 476.4

Anti-AVPR1B antibody

STJ71660 100 µg
EUR 430.8

Avpr1b Polyclonal Antibody

A53413-020 20 ul
EUR 117.7

Avpr1b Polyclonal Antibody

A53413-050 50 ul
EUR 302.5

Avpr1b Polyclonal Antibody

A53413-100 100 ul
EUR 423.5

Avpr1b Polyclonal Antibody

A53413
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Avpr1b/ Rat Avpr1b ELISA Kit

ELI-07676r 96 Tests
EUR 1063.2

AVP Conjugated Antibody

C47965 100ul
EUR 476.4

Anti-AVP antibody

STJ117784 100 µl
EUR 332.4
Description: This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20.

Anti-AVP antibody

STJ400041 1 mg
EUR 535.2
Description: Copeptin is a 39-amino acid glycopeptide, cleaved from the C-terminus of pre- provasopressin (pre-proAVP). It has been suggested as a biomarker in diagnosis and prognosis of several diseases, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.

Anti-AVP antibody

STJ400042 1 mg
EUR 535.2
Description: Copeptin is a 39-amino acid glycopeptide, cleaved from the C-terminus of pre- provasopressin (pre-proAVP). It has been suggested as a biomarker in diagnosis and prognosis of several diseases, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.

Anti-AVP antibody

STJ400043 1 mg
EUR 535.2
Description: Copeptin is a 39-amino acid glycopeptide, cleaved from the C-terminus of pre- provasopressin (pre-proAVP). It has been suggested as a biomarker in diagnosis and prognosis of several diseases, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.

Anti-AVP antibody

STJ400044 1 mg
EUR 535.2
Description: Copeptin is a 39-amino acid glycopeptide, cleaved from the C-terminus of pre- provasopressin (pre-proAVP). It has been suggested as a biomarker in diagnosis and prognosis of several diseases, such as acute myocardial infarction, heart failure, hyponatremia, and sepsis.

AVP Polyclonal Antibody

A54862-020 20 ul Ask for price

AVP Polyclonal Antibody

A54862-050 50 ul Ask for price

AVP Polyclonal Antibody

A54862-100 100 ul
EUR 423.5

AVP Polyclonal Antibody

A54862
  • EUR 684.66
  • Ask for price
  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

AVP Polyclonal Antibody

A71485
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

AVP Polyclonal Antibody

A71485-050 50 ul
EUR 302.5

AVP Polyclonal Antibody

A71485-100 100 ul
EUR 423.5

AVPR1B siRNA

20-abx908724
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AVPR1B siRNA

20-abx908725
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Avpr1b Antibody, HRP conjugated

1-CSB-PA15639B0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Avpr1b. Recognizes Avpr1b from Rat. This antibody is HRP conjugated. Tested in the following application: ELISA

Avpr1b Antibody, FITC conjugated

1-CSB-PA15639C0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Avpr1b. Recognizes Avpr1b from Rat. This antibody is FITC conjugated. Tested in the following application: ELISA

Avpr1b Antibody, Biotin conjugated

1-CSB-PA15639D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Avpr1b. Recognizes Avpr1b from Rat. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anti-AVPR1B (mouse) antibody

STJ71661 100 µg
EUR 430.8

Human Vasopressin V1b receptor (AVPR1B) ELISA Kit

abx251804-96tests 96 tests
EUR 886.8

Rat Vasopressin V1b receptor (AVPR1B) ELISA Kit

abx520989-96tests 96 tests
EUR 886.8

Mouse Vasopressin V1b receptor (AVPR1B) ELISA Kit

abx572461-96tests 96 tests
EUR 886.8

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) Protein

20-abx652577
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Arginine Vasopressin Receptor 1B (AVPR1B) Protein

20-abx652578
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

OVA Conjugated Arginine Vasopressin Receptor 1B (AVPR1B)

4-CPB263Hu21
  • EUR 259.78
  • EUR 193.20
  • EUR 644.16
  • EUR 294.72
  • EUR 469.44
  • EUR 249.60
  • EUR 1430.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Arginine Vasopressin Receptor 1B expressed in: chemical synthesis

Rat Avpr1b/ Vasopressin V1b receptor ELISA Kit

E0110Ra 1 Kit
EUR 775.2

Mouse Avpr1b/ Vasopressin V1b receptor ELISA Kit

E0151Mo 1 Kit
EUR 758.4

Rat Avpr1b(Vasopressin V1b receptor) ELISA Kit

ER0695 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Human AVPR1B(Vasopressin V1b receptor) ELISA Kit

EH2440 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human AVPR1B/ Vasopressin V1b receptor ELISA Kit

E0239Hu 1 Kit
EUR 726

Human Vasopressin V1b receptor, AVPR1B ELISA KIT

ELI-07674h 96 Tests
EUR 988.8

Mouse Vasopressin V1b receptor, Avpr1b ELISA KIT

ELI-07675m 96 Tests
EUR 1038

AVP siRNA

20-abx900562
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AVP siRNA

20-abx908728
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AVP siRNA

20-abx908729
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Arginine Vasopressin (AVP) Antibody

abx411676-50ul 50 ul
EUR 526.8

Arginine Vasopressin (AVP) Antibody

abx412424-01ml 0.1 ml
EUR 693.6

Polyclonal AVP Antibody (Center)

APG03184G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AVP (Center). This antibody is tested and proven to work in the following applications:

AVP Antibody, HRP conjugated

1-CSB-PA11069B0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVP. Recognizes AVP from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

AVP Antibody, FITC conjugated

1-CSB-PA11069C0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVP. Recognizes AVP from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

AVP Antibody, Biotin conjugated

1-CSB-PA11069D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AVP. Recognizes AVP from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

CMV-Null control Adenovirus

AVP-Null 1x109 IFU/ml x 200ul
EUR 418.8
Description: Pre-made Null-control Adenovirus , provided in DMEM medium.

AVPR1B Blocking Peptide

DF5170-BP 1mg
EUR 234

Polyclonal AVPR1B Antibody (C-term)

APR11474G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AVPR1B (C-term). This antibody is tested and proven to work in the following applications:

Polyclonal AVPR1B Antibody (C-Terminus)

APR11475G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AVPR1B (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal AVPR1B Antibody (C-Terminus)

APR11476G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AVPR1B (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal AVPR1B Antibody (Cytoplasmic Domain)

APR11477G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AVPR1B (Cytoplasmic Domain). This antibody is tested and proven to work in the following applications:

Polyclonal AVPR1B Antibody (N-Terminus)

APR11478G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AVPR1B (N-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal Goat Anti-AVPR1B Antibody

APR12076G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-AVPR1B . This antibody is tested and proven to work in the following applications:

Avpr1b Polyclonal Antibody, HRP Conjugated

A53414-050 50 ul
EUR 302.5

Avpr1b Polyclonal Antibody, HRP Conjugated

A53414-100 100 ul
EUR 423.5

Avpr1b Polyclonal Antibody, FITC Conjugated

A53415-050 50 ul
EUR 302.5

Avpr1b Polyclonal Antibody, FITC Conjugated

A53415-100 100 ul
EUR 423.5

Avpr1b Polyclonal Antibody, Biotin Conjugated

A53416-050 50 ul
EUR 302.5

Similar to in vivo study, the nuclear translocation of P53, mitochondrial and cell apoptosis dysfunction were observed in the H9C2 cells treated with LPS. Our data also indicates that SIRT2 reduced expression was associated with an increase in acetylation of P53 after the treatment of the LPS. In conclusion, TLR4 activation in rats promotes cardiac inflammation, mitochondrial dysfunction, apoptosis and fibrosis. P53 and CASPASE 7 / CASPASE 9 were found to play an important role in the apoptosis mediated by TLR4. Our data suggest that TLR4-mediated fibrosis reduction and apoptosis could be a new approach in the treatment of heart failure, taking into account the major role played by TLR4 in cardiac inflammation.

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